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Anticoagulant Effect of Ananas comosus (Pineapple) Peelings Extract in Male Mice.

Author

Publication Information

Publication Type
Thesis/Dissertations
Thesis Degree
MD
Publication Date
April 2017

Abstract

Pineapple (Ananas comosus) is the most common and readily available fruit found all over the world. Several studies showed the presence of bromelain in pineapple which is an effective anticoagulant, which prompted the purpose of this study and since the pineapple peelings are considered waste products, this study focuses on the utilizing the pineapple peelings only, in determining its anticoagulant effect in mice. Pineapple peeling extract were obtained, administered, and evaluated in 21 male, about 10-12 weeks old ICR mice for 2 weeks. The bleeding time was conducted during day 8. The clotting time and CBC were conducted on day 0 (pretest} and day 8 (post-test). The results obtained through the data analysis showed that there was a significant  difference in the appearance of the mice on day 3 and 4, between the negative and positive control, and the negative and experimental group. The clotting time on day 0 also showed significant difference between the negative and experimental group, and the positive and experimental group.

Objectives

To determine the anticoagulant effect of pineapple peeling extract in ICR mice.

References

1. Bekkevold, . Dehydration parameters and standards for laboratory mice , 2013
2. Cannon, Mendenhall . "Poisoning of wildlife with anticoagulant rodenticides in New York" , 2011
3. Kaur, Corscadden . "Methods of extraction, purification and therapeutic applications" Braz.arch.Biology.technol 59, May 2016
4. Zhou, . "Hemostatic therapy in experimental intracerebral hemorrhage associated with dibigatrin administrationn" , 2014
5. Roer, . "An important complication of anticoagulation therapy: a case presentation" , October 1995

Physical Location

LocationLocation CodeAvailable FormatAvailability
University of the Visayas - Gullas College of Medicine Library Fil.-T L962an 2017 Fulltext Print Format

 
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