Pineapple (Ananas comosus) is the most common and readily available fruit found all over the world. Several studies showed the presence of bromelain in pineapple which is an effective anticoagulant, which prompted the purpose of this study and since the pineapple peelings are considered waste products, this study focuses on the utilizing the pineapple peelings only, in determining its anticoagulant effect in mice. Pineapple peeling extract were obtained, administered, and evaluated in 21 male, about 10-12 weeks old ICR mice for 2 weeks. The bleeding time was conducted during day 8. The clotting time and CBC were conducted on day 0 (pretest} and day 8 (post-test). The results obtained through the data analysis showed that there was a significant difference in the appearance of the mice on day 3 and 4, between the negative and positive control, and the negative and experimental group. The clotting time on day 0 also showed significant difference between the negative and experimental group, and the positive and experimental group.
To determine the anticoagulant effect of pineapple peeling extract in ICR mice.
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